Cardiac Troponin I (cTnI)
– cTnI is a protein of 21kDa and is a thin filament of the heart muscle, playing an important role in the contraction of the muscle. If the myocardial cell is damaged, cTnI is detected in the circulatory bloodstream, so with cTnT, it is known as an important indicator of heart disease due to damage to the myocardial cell.
– Although cTnI is not detected in the blood of normal people or patients without heart disease, but is detected in the blood if there is necrosis of myocardial cells, so it is used for the diagnosis of acute myocardial infarction at early stage of myocardial injury.
Creatine Kinase MB (CK-MB)
– CK-MB accounts for 20% of myocardial proteins and is a relatively myocardial cell-specific enzyme. Therefore, CK-MB is a very useful marker for the diagnosis of acute myocardial infarction(AMI). If the level of this enzyme is high, the possibility of angina or myocardial infarction can be consider.
– Myoglobin is a pigment protein in myocardial or skeletal muscle that has a high affinity for oxygen and is an 18kD protein present in the cell fluid. It is released rapidly from ischemic damaged heart tissue. Because it is released into the circulating blood from the skeletal muscle even after the skeletal muscle disease or damage and the extreme exercise, it is necessary to use several cardiac markers to diagnose heart disease for accurate diagnosis
high sensitive CRP
– C-reactive CRP (CRP) is one of the most dramatically increased plasma proteins in diseases such as inflammatory diseases or necrosis of body tissues and is a representative component of acute phase proteins.
– CRP measurements are extremely useful in determining the presence of inflammatory or tissue-disruptive disease and its severity, progress, and prognosis. Chexel™ Cartridge is compatible with the Chexel™ Reader and allows quantitative analysis of samples.
– NT-proBNP is a marker for impaired cardiac function, which, apart from the symptoms of heart failure, increases with heart disease.
– NT-proBNP and BNP are used for the diagnosis of congestive heart failure. This is a state in which the heart can not supply the blood (especially oxygen) needed by the body’s tissues or organs due to a decrease in ventricular contractility (reduced myocardial contractility) or abnormal ventricular systolic function.