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LIQUID BIOPSY

Liquid biopsy is the sampling and analysis of non-solid biological tissue, primarily blood.

This type of technique is mainly used as a diagnostic and monitoring tool for diseases such as cancer, with added benefit of being largely non-invasive. The method may also be used to validate the efficiency of a cancer treatment drug, and prove beneficial for patients after treatment to monitor relapse. (Wikipedia)

“AFM allows to detect specific mutant genes in cell-free DNA very sensitively. In the case of BRAF V600E, it is useful for early diagnosis of recurrence in thyroid cancer surgery patients, and the diagnostic service will be started through a CLIA Laboratory in US from the second half of 2025.

We are also planning other diagnostic services as it has been demonstrated that KRAS G12X and G13X, which are biomarkers of various cancers, can be also applied, and developing panels that can analyze several selected biomarkers in parallel is under progress.

Advantages

01

Detection limit 3 copies and allele frequency less than 0.01%

02

Specificity ~ 100%

03

Small sample volume 1 mL – 5 mL blood

04

Multiplexing A single test can detect presence of KRAS G12X, G13X mutations.

05

Flexibility By simply changing sequence of the capture probe, it is possible to apply the method for other DNA biomarkers.